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Protein lysine methyltransferases constitute a large family of epigenetic writers that catalyse the transfer of a methyl group from the cofactor ...
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EPZ004777, a SAM-competitive pyrrolopyrimidine derivative designed as a potent, selective inhibitor of DOT1L, reduces global H3K79me2 levels, and selectively ...
The histone methyltransferase DOT1L: regulatory functions and a ...
www.ncbi.nlm.nih.gov › PMC4633909
This demonstrates the complex regulatory effects of DOT1L on a wide range of functions in eukaryotic organisms, with H3K79me and H3K79me2 associated with active ...
EED226 is a polycomb repressive complex 2 (PRC2) inhibitor, which binds to the K27me3-pocket on embryonic ectoderm development (EED) and shows strong antitumor ...
Missing: Transferase
Methylated DNA binds the transcriptional repressor, MeCP2, at the MBD, which recruits the Sin 3A/histone deacetylase complex to form the transcriptionally ...
May 26, 2016 · In a ternary complex mechanism, inhibitors ... inhibitory potency (K i) for a HAT inhibitor. ... histone acetyltransferase inhibitor, represses ...
Mar 24, 2017 · In this review, we focus on the enzymes that are responsible for the methylation and demethylation of histone and nonhistone proteins, namely, ( ...
The MMSET gene undergoes complex alternative splicing and differential promoter usage, giving rise to a number of different transcripts from the locus, most of ...
Histone methyltransferase Dot1L recruits O-GlcNAc transferase to ...
www.jbc.org › article › fulltext
Jun 8, 2022 · These results demonstrate that although Dot1L was O-GlcNAcylated, inhibition of the enzymatic activity or deletion of OGT or OGA had exerted no ...
Dec 13, 2021 · Protein lysine methyltransferases constitute a large family of epigenetic writers that catalyse the transfer of a methyl group from the cofactor ...